Mediterranean Journal of Hematology and Infectious Diseases
نویسندگان
چکیده
Apart from its well known role as an etiological agent for non hepatitis, there is growing evidence that hepatitis C virus is associated to B lymphoma. The association between HCV and lymphoproliferative disorders has bee recently postulated based on epidemiological data, biological studies and clinical observations. Although various subtypes of lymphomas appear to be associated to HCV, diffuse large B lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia lymphoma appeared to be particularly represented among HCV causative role of HCV in those disorders has been further supported by the response to anti viral therapy. Despite a better understanding of pathophysiolo from HCV infection to overt lymphoma, many issues still need to be further elucidated. Although HCV has been demonstrated to directly infect peripheral blood mononuclear cells both in vitro and, in some cases, hypothesis of an indirect transformation mechanism by which sustained antigenic stimulation leads from oligoclonal to monoclonal expansion and sometimes to lymphoma, probably through secondary oncogenic events. Her as well as clinical data on antiviral therapy, linking HCV lymphoma. Introduction: Hepatitis C virus (HCV) is a small (9600 nucleotide) encapsulated positive strand RNA member of the Flaviviridae family. The virus lacks a reverse-transcriptase and its genome encodes a single open reading frame for a large polyprotein, which is subsequen www.mjhid.org ISSN 2035-3006
منابع مشابه
Introducing Mediterranean Journal of Hematology and Infectious Diseases
Mediterranean Journal of Hematology and Infectious Diseases (MJHID) is a new open access, peer-reviewed, online journal, which encompasses different aspects of clinical and translational research providing an insight into the relationship between acute and chronic infections and hematological diseases. MJHID will be a topical journal on subjects of current importance in clinical haematology and...
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تاریخ انتشار 2012